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NCT-501

Product Name
NCT-501
CAS No.
1802088-50-1
Chemical Name
NCT-501
Synonyms
CS-2069;NCT-501;NCT-501 >=98% (HPLC);Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
CBNumber
CB73043300
Molecular Formula
C21H32N6O3
Formula Weight
416.52
MOL File
1802088-50-1.mol
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NCT-501 Property

Boiling point:
627.3±65.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
form 
solid
pka
5.26±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21162
Product name
NCT-501
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21162
Product name
NCT-501
Purity
≥98%
Packaging
5mg
Price
$233
Updated
2024/03/01
Cayman Chemical
Product number
21162
Product name
NCT-501
Purity
≥98%
Packaging
10mg
Price
$412
Updated
2024/03/01
Cayman Chemical
Product number
21162
Product name
NCT-501
Purity
≥98%
Packaging
25mg
Price
$887
Updated
2024/03/01
AK Scientific
Product number
4502EC
Product name
8-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione
Packaging
25mg
Price
$1086
Updated
2021/12/16
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NCT-501 Chemical Properties,Usage,Production

Description

NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC50 = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.

References

yang s m, yasgar a, miller b, et al. discovery of nct-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1)[j]. journal of medicinal chemistry, 2015, 58(15): 5967-5978.

NCT-501 Preparation Products And Raw materials

Raw materials

Preparation Products

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NCT-501 Suppliers

China 68 United States 10 Global 78
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
Advantage
65

1802088-50-1, NCT-501Related Search:


  • NCT-501
  • CS-2069
  • 1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
  • NCT-501 >=98% (HPLC)
  • Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501
  • 8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
  • 1802088-50-1